Angiotensin Receptor
Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.
Angiotensin Receptor Isoform Specific Products
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Angiotensin Receptor Inhibitors
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Angiotensin Receptor Agonists
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Angiotensin Receptor Antagonists
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Angiotensin Receptor Activators
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Angiotensin Receptor Modulators
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Angiotensin Receptor Chemicals
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Angiotensin Receptor Ligands
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Angiotensin Receptor Related Products (295)
Related Products (295)
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Antibodies (7)
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Angiotensin Receptor Isoform Comparison
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AT1R antagonist 4
0 ImagesCat. No.: HY-180443CAS No.: 2982582-16-9AT1R antagonist 4 (Example 26) is an AT1R antagonist. AT1R antagonist 4 shows excellent antagonistic activity against calcium influx in cells stably expressing AT1 receptors and ETA receptors. AT1R antagonist 4 can be used in kidney disease research.
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Benzyl benzoate (Standard)
0 ImagesBenzyl benzoate (Standard) is the analytical standard of Benzyl benzoate. This product is intended for research and analytical applications. Benzyl benzoate (Phenylmethyl benzoate) is an orally active anti-scabies agent, acaricide (EC50= 0.06 g/m2) and fungicide. Benzyl benzoate is an angiotensin II (Ang II) inhibitor with antihypertensive effects. Benzyl benzoate can be used in perfumes, pharmaceuticals and the food industry.
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Losartan Carboxylic Acid (Standard)
0 ImagesSynonyms: E-3174 (Standard); EXP-3174 (Standard)Losartan Carboxylic Acid (Standard) is the analytical standard of Losartan Carboxylic Acid. This product is intended for research and analytical applications. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[4].
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Azilsartan (Standard)
0 ImagesSynonyms: TAK-536 (Standard)Azilsartan (Standard) is the analytical standard of Azilsartan. This product is intended for research and analytical applications. Azilsartan (TAK-536) is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research.
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Buloxibutid (Standard)
0 ImagesCat. No.: HY-100113RCAS No.: 477775-14-7Synonyms: AT2 receptor agonist C21 (Standard)Buloxibutid (AT2 receptor agonist C21) (Standard) is the analytical standard of Buloxibutid (HY-100113). This product is intended for research and analytical applications. Buloxibutid is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid exerts effects such as vasodilation, anti-inflammation, anti-fibrosis (promoting the expression of collagenase MMP-13) and tissue repair mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway as well as the inflammatory NF-κB pathway. Buloxibutid can be used in research related to idiopathic pulmonary fibrosis, hypertension, and systemic sclerosis.
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Talfirastide (Standard)
0 ImagesCat. No.: HY-12403RCAS No.: 51833-78-4Synonyms: TXA127 (Standard); Angiotensin (1-7) (Standard); Ang-(1-7) (Standard)Talfirastide (Standard) is the analytical standard of Talfirastide. This product is intended for research and analytical applications. Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity .
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Candesartan Cilexetil-d11
0 ImagesCat. No.: HY-W707384CAS No.: 1261393-19-4Synonyms: TCV-116-d11Candesartan Cilexetil-d11 (TCV-116-d11) is deuterium labeled Candesartan Cilexetil. Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure.
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ZD-6888 hydrochloride
0 ImagesCat. No.: HY-19156ACAS No.: 138620-17-4Synonyms: ICI-D 6888 hydrochlorideZD-6888 hydrochloride (ICI-D 6888 hydrochloride) is an antagonist for angiotensin II, which competitively inhibits the angiotensin II-mediated release of renin, affects the renal structure and function.
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Valsartan methyl ester (Standard)
0 ImagesSynonyms: CGP 48933 methyl ester (Standard)Valsartan (CGP 48933) methyl ester (Standard) is the analytical standard of Valsartan methyl ester (HY-W414915). This product is intended for research and analytical applications. Valsartan methyl ester is the methyl ester derivative of Valsartan (HY-18204). Valsartan is a selective angiotensin II type 1 (AT1) receptor blocker (ARB) with potent antihypertensive and cardioprotective effects. Valsartan competitively binds to AT1 receptors, inhibiting the binding of angiotensin II to AT1 receptors, thereby blocking angiotensin II-mediated vasoconstriction, sodium retention, and myocardial hypertrophy signaling pathways. Valsartan reduces systolic blood pressure in L-NAME-induced hypertensive rats. Valsartan can be used for the study and treatment of arterial hypertension, hypertensive heart disease, and heart failure.
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Losartan (Standard)
0 ImagesSynonyms: DuP-753 (Standard)Losartan (Standard) is the analytical standard of Losartan. This product is intended for research and analytical applications. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
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Tolonidine (Standard)
0 ImagesTolonidine (Standard) is the analytical standard of Tolonidine. This product is intended for research and analytical applications. Tolonidine is a derivative of imidazoline. Tolonidine is orally active and has been shown to possess hypotensive and antihypertensive properties.
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1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone
![1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone](https://file.medchemexpress.com/product_pic/hy-n9520.gif "Click to View 1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone Product Detail")
0 ImagesCat. No.: HY-N9520CAS No.: 120693-52-9Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is an antagonist of angiotensin II receptor (IC50=48.2 μM). Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is a quinolone alkaloid from Evodia rutaecarpa.
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L 158338
0 ImagesCat. No.: HY-117627CAS No.: 133240-38-7L 158338 is an angiotensin II receptor antagonist. L 158338 alleviates acidosis and increases coronary blood flow during the ischemic period and increases coronary blood flow during the reperfusion period. L 158338 can be used to study myocardial injury during ischemia and reperfusion.
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Irbesartan-d7 hydrochloride
0 ImagesCat. No.: HY-B0202ASSynonyms: SR-47436-d7 hydrochloride; BMS-186295-d7 hydrochlorideIrbesartan-d7 hydrochloride is deuterated labeled Irbesartan hydrochloride (HY-B0202A). Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease.
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Candesartan methyl ester (Standard)
0 ImagesCat. No.: HY-W098792RCAS No.: 139481-69-9
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Azilsartan medoxomil monopotassium (Standard)
0 ImagesCat. No.: HY-17458RCAS No.: 863031-24-7Synonyms: Azilsartan kamedoxomil (Standard); TAK 491 monopotassium (Standard)Azilsartan medoxomil monopotassium (Standard) is the analytical standard of Azilsartan medoxomil monopotassium (HY-17458V). This product is intended for research and analytical applications. Azilsartan medoxomil (TAK 491) monopotassium, a prodrug form of Azilsartan (HY-14914), is an orally active angiotensin II receptor type 1 antagonist. Azilsartan medoxomil monopotassium can be used for the study of essential hypertension.
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Elisartan
0 ImagesCat. No.: HY-19214CAS No.: 149968-26-3Synonyms: HN 65021Elisartan is an orally active non-peptide pro-agent of angiotensin II AT1 receptor antagonist HN-12206, and shows anti-hypertension activities.
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CGP48369
0 ImagesCat. No.: HY-101706CAS No.: 135689-23-5CGP48369 is a nonpeptidic angiotensin II receptor antagonist, used for anti-hypertensive research.
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L-159282
0 ImagesCat. No.: HY-19191CAS No.: 157263-00-8Synonyms: MK 996L-159282 is a highly potent, orally active, nonpeptide angiotensin II receptor antagonist, with anti-hypertensive activity.
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L162389
0 ImagesL162389 is a potent antagonist of angiotensin AT1 receptor with Ki of 28 nM.
